ALFAZOL ORAL TABLET

For Animal Use Only

ALFAZOL

Oral Tablet

Veterinary Anthelmintic

COMPOSITION

Alfazol Oral Tablet, Each tablet, which is white–off-white in color and with two notches, contains 1200 mg of Albendazole.

PHARMACOLOGICAL PROPERTIES

Albendazole is a broad-spectrum anthelmintic belonging to the benzimidazole carbamate chemical group. It acts by inhibiting the effectiveness of Fumarate Reductase, which is in the glucose metabolism of the parasites, and by disrupting the energy metabolism of the parasites. At the end of this degradation, the use of glycogen increases and the parasite dies. Albendazole reaches peak plasma concentration in cattle 6 hours after administration. Albendazole is rapidly distributed in body fluids and tissues, and its plasma level rarely exceeds 1%. The product is metabolized to Sulphoxide and Sulphone compounds. As a single dose, oral albendazole is excreted in the urine, 28% in the first 24 hours and 47% in the 9-day period.

AREA OF USE/INDICATIONS

Alfazol Oral Tablet is used for the treatment and protection of adults, larvae and eggs of cattle gastrointestinal, lung pinworms, adults and eggs of liver flukes, adult and young forms of stripes and infestations.

Effective against following parasites

CATTLE:

Stomach – intestinal pinworms: Trichostrongylus sp., Oesophagostomum sp., Haemonchus sp., Cooperia sp., Ostertagia sp., Bunostomum sp., Chabertia sp., Gaigeria pachyscelis, Nematodirus sp., Strongyloides sp., Trichuris sp.

Lung worms: Dictyocaulus viviparus.

Liver butterflies; Fasciola hepatica, F. gigantica, Dicrocoelium dentriticum.

Tapeworms; Moniezia sp.

USAGE AND DOSAGE

Unless recommended otherwise by the veterinarian, the pharmacological dose for cattle gastro-intestinal, lung pinworms is 7.5 mg/kg body weight, for tapeworms – 10 mg/kg body weight, for F. hepatica and F. gigantica – 15 mg/kg body weight, for D. dentriticum – 20 mg/kg body weight.

Tablets are administered by swallowing orally at one time. Tablets can also be used as half tablets by breaking the notch in the middle when necessary.

PRACTICAL DOSAGE

SPECIFIC CLINICAL INFORMATION AND WARNINGS FOR TARGET SPECIES

It is appropriate to give albendazole tablets to cattle in the recommended doses in spring and autumn within the scope of parasitic control. It should be used in the recommended dose according to the results of the veterinarian’s examination in terms of butterflies, sand butterflies, stripes and pinworms.

UNDESIRED EFFECTS

There are no known side effects at recommended doses.

DRUG INTERACTIONS

Albendazole has no known incompatibility with other drugs.

SYMPTOMS OF OVERDOSE, PRECAUTIONS AND ANTIDOTE

Alfazol Oral Tablet can be used safely in weak, sick, very young animals at recommended doses. It is safe in doses up to five times. It causes liver toxicity at higher doses. In this case, symptomatic treatment is applied.

RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS

Drug Residue Elimination Period: During the treatment process and after the last drug administration, cattle should not be sent to slaughter until 14 days after. During the treatment and after the last drug administration, cow’s milk should not be offered to human consumption for 3 days (6 milkings).

CONRAINDICATIONS

Use in Pregnancy: Albendazole should not be used during the first 45 days of pregnancy and during ramming, as it has the potential for teratogenic effects.

GENERAL PRECAUTIONS

Consult your veterinarian before use and in case of an unexpected effect. Keep out of reach of children.

STORAGE CONDITIONS AND SHELF LIFE

It should be stored at room temperature (15-25 °C) and in a dry place, protected from sunlight. Shelf life is 2 years from the date of manufacture.

TRADE DRESS

Alfazol Oral Tablet, is offered for sale in blister packs of 10, 20, 50 and 100 tablets in a cardboard box, covered with aluminum foil.

PLACE AND CONDITIONS OF SALE

With a veterinarian’s prescription; Sold in pharmacies and veterinary practice.