CAN ONLY BE USED IN ANIMAL HEALTH
CHRONO-GEST/PMSG
INJECTABLE SOLUTION POWDER
LYOPHILIZED SERUM GONADOTROPIN
COMPONENTS
It consists of a transparent vial containing 6000 IU white lyophilized PMSG powder and 25 ml of sterile colorless, transparent solvent. Each ml of the injection solution mixed with its solvent contains 240 IU Gonadotropin hormone (PMSG).
PHARMACOLOGICAL PROPERTIES
Serum gonadotropin (PMSG) is a glycoprotein hormone isolated from the serum of pregnant mares and has a high stimulation effect on the reproductive glands. Chrono-Gest PMSG was extracted from pregnant mare serum using special methods and then lyophilized. PMSG has both significant FSH (follicle stimulation hormone) and LH (luteinizing hormone) activity. In females, FSH activity causes maturation stimulation and estrogen secretion from theca and granulose cells in the ovaries.
CHRONO-GEST/PMSG is used together with a progestin (CHRONO-GEST/sponge) to regulate the rutting in sheep. Estrus(rutting) delayed until the desired time with progestin; It is initiated by discontinuing progestin administration and administering pregnant mare serum gonadtropin (PMSG) at the same time. Thus, follicles are formed and ovulation occurs.
Since gonadtropins of pituitary or placental origin are destroyed by enzymes of the gastrointestinal tract, they are effective only when administered parenterally. Since PMSG has a larger molecular weight than other gonadotropins, it cannot pass through the renal filter, so it has a longer duration of action. PMSG disperses slowly after intramuscular injection and is absorbed by the tissues. It is metabolized in the liver and removed from the organism. It reaches maximum serum concentrations in 12-24 hours and the average elimination half-life from the body varies between 40-125 hours.
AREA OF USE/INDICATIONS:
It is used for estrus induction and synchronization in adult and young sheep by applying it after the completion of progestin (flugestone acetate = CHRONOGEST sponge) treatment.
USAGE AND DOSAGE
Chronogest PMSG is administered intramuscularly after dilution with solvent. Diluted PMSG must be used immediately. When the 6000 IU ampoule is mixed with 25 ml diluent, a solution for injection with a concentration of 240 IU PMSG/ml is obtained.
PMSG dose varies between 250-750 IU depending on various situations.
Normally, 400-700 IU of PMSG is used in adult females during the anoestrus period and 300-600 IU of PMSG during the estrus period.
As a practical dose, 1 ml solution gives 240 IU, 2 ml solution gives 480 IU, 2.5 ml solution gives 600 IU, 3 ml solution gives 720 IU. The application is administered intramuscularly.
In principle in practice;
- Higher dose for non-lactating animals than for lactating animals,
- High doses are preferred in herds with low twinning rates.
- The PMSG dose decreases as the time elapses after the last lambing increases. In other words, if a short time has passed since the last lambing, a high dose is used, and if a long time has passed, a low dose is used.
- A higher dose is applied in herds showing deep seasonal anoestrus, and a lower dose is applied in herds showing mild seasonal anoestrus.
The proximity of progestin (CHRONO-GEST sponge) administration to the middle of the estrous season affects the PMSG dose. The PMSG dose decreases as it approaches the middle of the estrus season.
SPECIAL CLINICAL FACTS AND WARNINGS FOR TARGET SPECIES
In PMSG application, low doses stimulate the ovaries, medium doses increase twinning, and high doses cause superfolliculation. When dosing, the purpose for which the application will be applied should be determined in advance.
In addition, the animal’s size, genotypic structure, cyclic status, nutrition and environmental factors, and other applied treatments should also be taken into consideration. Since multiple ovulations may occur if applied in sufficient amounts, it is more appropriate to perform insemination during the following estrus, especially when multiple fertilization is desired to be avoided in animals such as cattle. It can be applied to sheep both during the breeding season and at any time of the year, including the anoestrus period. It is recommended to record the CHRONO-GEST PMSG application date, dose, sheep type, and results for subsequent applications.
UNDESIRED/SIDE EFFECTS
Because it has a peptide structure, PMSG can cause sensitization reactions that can range from urinary tract to anaphylactic shock. By administering high doses of PMSG, uncontrolled superovulation, high mortality rate of double, triple or quadruple births or high embryo mortality may occur.
DRUG INTERACTIONS
It should not be used simultaneously with progesterone preparations.
SYMPTOMS, PRECAUTIONS AND ANTIDOTE IN OVERDOSE
As with other protein preparations at high doses, an anaphylactic reaction may occur. In these cases, glucocorticoid, antihistamine and epinephrine administration is recommended.
WARNINGS ABOUT DRUG RESIDUES IN FOOD
Drug Residue Purification Period (D.R.P.P.): The residue purification period for meat and milk is “0” days.
CONTRAINDICATIONS
Use during Pregnancy: Use in pregnant animals is contraindicated.
In animals that have experienced a PMSG allergic reaction,
In females with polycystic ovaries,
It should not be used in animals with estrogen-sensitive tumor formations.
GENERAL WARNINGS
Consult your veterinarian before use and if any unexpected effects occur.
Keep it out of reach of children.
PRECAUTIONS TO BE TAKEN BY THE PRACTITIONER AND WARNINGS FOR PHYSICIANS
Sensitive practitioners should be wary of accidental self-injection, as it may cause allergic or anaphylactic reactions.
HOW TO STORE AND SHELF LIFE
It should be stored in the shade at 6-15°C. If an environment below 15°C cannot be provided, it is stored in a refrigerator (2-8°C). Once diluted and thawed, it should be used within 12 hours.
The expiration date is 3 months from the date of manufacture.
WARNINGS FOR END OF USE DISPOSAL AND NON-TARGET SPECIES
It is removed appropriately. It should not be thrown into the environment haphazardly.
COMMERCIAL PRESENTATION SHOWING THE QUALITY AND QUANTITY OF THE PACKAGING
Multi-dose vials
In a cardboard box with 1 colorless glass vial of 5000 IU and 25 ml sterile colorless, transparent solvent.
6000 IU colorless glass vial with 25 ml sterile colorless, transparent solvent in a cardboard box
Single dose vialsIn a cardboard box with 5 colorless glass vials of 400, 500, 600 and 700 IU, and 1 10 ml sterile colorless transparent solvent for every five vials.
In cardboard boxes with 50 colorless glass vials of 400, 500, 600 and 700 IU and 2 pieces of 50 ml (100 ml in total) sterile colorless transparent solvent for each 50 vials.
SALES LOCATION AND CONDITIONS
It is sold in pharmacies and veterinary offices with a veterinarian’s prescription (VHR).
