Can Only Be Used in Animal Health
DODEKS
Injectable Solution
Vitamin
COMPONENTS
DODEKS Solution for Injection is a sterile, red, clear solution and contains hydroxycobalamin chloride equivalent to 2 mg hydroxycobalamin (Vitamin B₁₂) as the active ingredient in each ml and 10 mg benzyl alcohol for antimicrobial preservative purposes. The active ingredient contains 10% exex dose.
PHARMACOLOGICAL PROPERTIES
DODEKS Solution for Injection contains hydroxycobalamin, which has vitamin B₁₂ activity. Vitamin B₁₂ plays a role as a coenzyme in various metabolic functions, such as carbohydrate and fat metabolism and protein synthesis. It also plays a role in blood formation and development in all domestic animals. Methionine is an essential vitamin for growth, cell proliferation, hematopoiesis, nucleoprotein and myelin synthesis, due to its effects on folic acid and malonic acid metabolisms. It is also necessary in the conversion of ribonucleic acid (RNA) to deoxyribonucleic acid (DNA). It is one of the basic substances required for cell division. In healthy ruminants, vitamin B₁₂ does not need to be given externally. In cobalt deficiency, vitamin B₁₂ synthesis stops. At the same time, vitamin B₁₂ synthesis is disrupted in various disorders of the rumen. In case of vitamin B₁₂ deficiency, development stops in all animals, sensitivity increases, hair becomes swollen and dermatitis begins. The voice disappears and coordination of movements occurs. Pain develops in the joints, and mild or moderate monocytic anemia occurs. Irregularities due to vitamin B₁₂ deficiency in the digestive system are; It is observed as loss of appetite, vomiting and diarrhea. The synthesis of vitamin B₁₂, like all B vitamins, slows down or stops in cases where the rumen microflora balance is disrupted, in all kinds of food-borne indigestions such as rumen acidosis and alkalosis, and in gastrointestinal infections. Additionally, absorption is inhibited. Vitamin B₁₂ is absorbed from the lower parts of the ileum (except in cases of malabsorption). It is largely bound to plasma proteins. 90% of it accumulates in the liver and a small amount in the kidneys. Excretion occurs through bile. Amounts exceeding the daily requirement are excreted unchanged in the urine.
AREA OF USE/ INDICATIONS
DODEKS Solution for Injection is used as a supplement to the main treatment in cases where absorption is hindered such as rumen acidosis and alkalosis, and in anemias caused by internal parasites and blood parasites such as anaplasmosis, piroplasmosis, thyrleriosis, especially hyperchromic and monocytic anemia, in accelerating development in young animals, in dermatitis due to vitamin B₁₂ deficiency, It is indicated in cases of loss of appetite and fatigue. It is also used together with vitamins B₁ and B₆ in disorders of the central and peripheral nervous system caused by various reasons (infectious, toxic, traumatic, metabolic deficiencies, etc.).
USAGE AND DOSAGE
The pharmacological dose of vitamin B₁₂ is 20 mcg/kg for cattle, horses, sheep and goats, and 20 mcg/kg for cats and goats.
In dogs it is 40 mcg/kg. Accordingly, practical doses are applied as follows.
| Cattle – Horse | 3 – 7 ml |
| Calf – Calf- Foal | 1 – 3 ml |
| Sheep – Goat | 0.5 ml – 1 ml |
| Lamb – Kid | 0.25 ml – 0.5 ml |
| Cat – Dog | 0.25 ml – 0.5 ml |
DODEKS Injectable Solution is used intramuscularly or subcutaneously in large and small cattle. These daily doses are administered for as long as deemed necessary. For intramuscular or subcutaneous applications, follow the rules of asepsis and antisepsis.
UNDESIRED EFFECTS
Although rare, anaphylactic reactions (skin rash, itching, etc.) and diarrhea may occur after parenteral administration.
Use during pregnancy: No studies on its use during pregnancy have yet been conducted in humans or animals.
DRUG INTERACTIONS
Anticoagulant drugs and potassium can block the absorption of Vitamin B₁₂ from the digestive tract. Parenteral chloramphenicol may reduce the effect of hydroxycobalamin used to treat anemia.
RESIDUAL WARNINGS FOR FOOD PRODUCING ANIMALS
Drug Residue Elimination Period: It is “0” days for meat and milk.
CONTRAINDICATIONS
No contraindications were found.
GENERAL WARNINGS
Consult your veterinarian before use and if any unexpected effects occur. Keep it out of reach of children.
STORAGE CONDITIONS AND SHELF LIFE
The shelf life is 48 months from the date of production when stored in its original packaging, at room temperature below 25°C, protected from heat and light, without being placed in the refrigerator or freezer. After the product is first opened, it should be stored at room temperature below 25°C, protected from heat and light, without being placed in the refrigerator or freezer, and should be used within 28 days. The corks of the bottles can be pierced a maximum of 40 times.
WARNINGS FOR END OF USE DISPOSAL AND NON-TARGET SPECIES
Any unused veterinary medicinal product or its discarded materials must be disposed of in accordance with the requirements of local laws. Any waste/residue material should not be disposed of into wastewater or drainage systems.
TRADE DRESS
It is offered for sale in 50 ml honey-coloured, Type I glass bottles closed with a red rubber stopper and white flip-off cap in a cardboard box.
SALES LOCATION AND CONDITIONS
It is sold in pharmacies and veterinary offices with a veterinarian’s prescription (VHR).
